National Institute for Health Research
Collaboration for Leadership in
Applied Health Research and Care

East Midlands
University of Nottingham
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Randomised controlled trial of the clinical and cost effectiveness of a specialist mood disorders team for refractory unipolar depressive disorder

What we are doing:

Measuring implementation of NICE guidelines for depression so that the standard of care offered by both treatment as usual and the specialist mood disorder team can be judged externally.

Why we are doing it:

Mental disorder accounts for 40 per cent of all disability in Europe and 40 per cent of incapacity benefitclaims in England. In 1990, unipolar depression was the fourth leading cause of “disability adjusted life years” in the world and by 2020 it is projected to be the second leading cause. The majority of suicides are associated with unipolar depression. Suicides in East Midlands have increased by one per cent in contrast toa national drop of six per cent (Anderson, 2006).

Mood Disorder main
 Mood   Disorders
Specialist team for  unipolar depression

Principal Investigator: Prof Richard Morriss 
Lead Researcher: Dr Catherine Kaylor-Hughes


What the benefits will be:

Improved care for patients with a clinical diagnosis of unipolar depressive disorder that has not been resolved within six months in three local mental health services. We also aim to understand whether better implementation of standard care outlined by NICE guidelines for depression or enhanced specialist careproviding pharmacotherapy and psychotherapy is required.

We are also exploring the feasibility and usefulness of research on the implementation processes, identifying barriers, drivers and distortions of care and evidence of effectiveness. This will usefully inform local commissioning and the implementation of clinically and cost effective care for high utilisers of care withunipolar depression.

Mood Disorder video

Who we are working with:

Now in follow up, the Specialist Mood Disorder Team consists of a psychiatrist and an experienced cognitive behaviour therapist who work together. We are working with:

  • University of Nottingham
  • Nottingham NHS Trust Healthcare
  • Cambridgeshire & Peterborough NHS Foundation Trust
  • Derbyshire Healthcare Foundation Trust
  • Lincolnshire Partnership NHS Foundation Trust
  • Nottingham County & City CCG
  • CLAHRC East of England
  • MRC Brain and Cognition Unit, University of Cambridge


Jayne Simpson



NIHR CLAHRC East Midlands


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